Blar i forfatter "Hintz, Mandy"

Viser treff 1-8 av 8

    • The challenge of durable brain control in patients with brain-only metastases from breast cancer 

      Nieder, Carsten; Oehlke, Oliver; Hintz, Mandy; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-07)
      The vast majority of patients with brain metastases from breast cancer have extracranial metastases, e.g., in the liver, lungs or bones, with serious impact on prognosis. Limited research has been performed on patients with brain-only disease. We analyzed patterns of treatment, brain control and survival in uni- and multivariate analyses. All 25 patients with brain-only disease were treated with ...

    • External Validation of the Graded Prognostic Assessment in Patients with Brain Metastases from Small Cell Lung Cancer 

      Nieder, Carsten; Popp, Ilinca; Hintz, Mandy; Grosu, Anca Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-29)
      Background: Recently, graded prognostic assessment (GPA) for small cell lung cancer (SCLC) patients with brain metastases has been developed. This includes age, performance status, number of brain metastases and presence of extracranial metastases. The aim of the present study was to validate this four-tiered prognostic score in a European cohort of patients. Methods: The retrospective validation ...

    • Hippocampus-avoidance whole-brain radiation therapy with a simultaneous integrated boost for multiple brain metastases 

      Popp, Ilinca; Rau, Stephan; Hintz, Mandy; Schneider, Julius; Bilger, Angelika; Fennell, Jamina Tara; Heiland, Dieter Henrik; Rothe, Thomas; Egger, Karl; Nieder, Carsten; Urbach, Horst; Grosu, Anca-Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-06)
      <i>Background</i> - The current study was aimed at investigating the feasibility of hippocampus‐avoidance whole‐brain radiation therapy with a simultaneous integrated boost (HA‐WBRT+SIB) for metastases and at assessing tumor control in comparison with conventional whole‐brain radiation therapy (WBRT) in patients with multiple brain metastases.<p> <p><i>Methods</i> - Between August 2012 and December ...

    • Long-term survival results after treatment for oligometastatic brain disease 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Aim - The aim of this study was to characterize the survival results of patients with up to four brain metastases after intense local therapy (primary surgery or stereotactic radiotherapy) if extracranial metastases were absent or limited to one site, e.g. the lungs.<p> <p>Background - Oligometastatic disease has repeatedly been reported to convey a favorable prognosis.<p> <p>Material and ...

    • Short survival time after palliative whole brain radiotherapy: Can we predict potential overtreatment by use of a nomogram? 

      Nieder, Carsten; Norum, Jan; Hintz, Mandy; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-01)
      Background:<br> Many patients with brain metastases undergoing whole brain radiotherapy (WBRT) have very limited survival. The purpose of this study was to validate a nomogram derived from a large American database and to examine its ability to better predict short survival (cut -off 2 months) than previous models. <br>Material and Methods: <br> This retrospective study included 254 European patients ...

    • Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA) 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)
      <i>Purpose</i> - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).<p><p> <i>Patients and Methods</i> - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain ...

    • Validation of the graded prognostic assessment for lung cancer with brain metastases using molecular markers(lung-molGPA) 

      Nieder, Carsten; Hintz, Mandy; Oehlke, Oliver; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-26)
      Background:<br>Many patients with brain metastases from non-small cell lung cancer have limited survival, while others survive for several years, depending on patterns of spread, EGFR and ALK alterations, among others. The purpose of this study was to validate a new prognostic model (Lung-molGPA) originally derived from a North American database.<br>Patients and methods:<br>This retrospective study ...

    • Validation of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA). 

      Nieder, Carsten; Hintz, Mandy; Bilger, Angelika; Oehlke, Oliver; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03)
      Background: It has been suggested to replace the diagnosis-specific graded prognostic assessment (DS-GPA, based on performance status and number of brain metastases) for patients with primary malignant melanoma with the new Melanoma-molGPA. The latter is a more complex assessment, which also includes BRAF mutation status, age and extracranial metastases. To test the performance of the Melanoma-molGPA, ...